Despite copious amounts of detailed physiological and molecular data, the mechanistic regulation of growth in pollen tubes still lacks a consensual integrative model. Transcriptomics reveals the presence of about 7.000 genes, but theoretical modeling shows that cooperation of all of these into two processes- wall surface and cytoplasmic volume production- is condition enough to all the morphogenic events that characterize these cells. Spatial and temporal integration of extended biochemical and biophysical processes is mandatory, and in the past we have propose and demonstrated that, at some levels, ion dynamics is common denominator of these regulatory mechanisms. To test the hypothesis that membrane transport activity is sufficient condition for the formation of the intracellular patterns of cytosolic ion concentration, we developed stringent 3-D theoretical modeling of ion fluxes and cytosolic diffusion based on the current knowledge of the system. These models showed that while the current knowledge about membrane fluxes is sufficient to explain cytosolic pH patterning, it is not for Ca2+, where intracellular sequestering must play a role. We will further discuss the minimal needs for channels to explain all the available evidence, and will present physiological, molecular and genetic data showing the presence of novel chloride and calcium influx mechanisms.